"The doctor of the future will give no medicine, but will interest his patients in the care of the human frame, in diet and in the cause and prevention of disease."
- Thomas Edison
Masters: Poisoning the Well: Neurotoxic Metals, Water Treatment, and Human Behavior 9.2.99
Plenary Address to Annual Conference of the Association for Politics and the Life Sciences
Four Seasons Hotel, Atlanta, GA -- 9:00AM, Sept. 2, 1999
Poisoning the Well: Neurotoxic Metals, Water Treatment, and Human Behavior
Roger D. Masters Department of Government, Dartmouth College
Foundation for Neuroscience and Society
SiF treated water can increase the transport of heavy metals across the gut-blood and blood-brain barriers, increasing rates of toxic uptake and behavioral dysfunction. Minorities are especially at risk. The brain is the most sensitive chemical organ in the body. ... In contemporary society, these effects take on a different character. Environmental pollution and dangerous water treatment procedures are human activities whose results are both economically costly and morally unjust. Innocent children should not be poisoned by public water supplies.
Summary: Heavy metals compromise normal brain development and neurotransmitter function, leading to long-term deficits in learning and social behavior. At the individual level, earlier studies revealed that hyperactive children and criminal offenders have significantly elevated levels of lead, manganese, or cadmium compared to controls; high blood lead at age seven predicts juvenile delinquency and adult crime. At the environmental level, our research has found that environmental factors associated with toxicity are correlated with higher rates of anti-social behavior. For the period 1977 to 1997, levels of violent crime and teenage homicide were significantly correlated with the probability of prenatal and infant exposure to leaded gasoline years earlier. Across all U.S. counties for both 1985 and 1991, industrial releases of heavy metals were -- controlling for over 20 socio-economic and demographic factors -- also a risk-factor for higher rates of crime. Surveys of children's blood lead in Massachusetts, New York, and other states as well as NHANES III and an NIJ study of 24 cities point to another environmental factor: where silicofluorides are used as water treatment agents, risk-ratios for blood lead over 10µg/dL are from 1.25 to 2.5, with significant interactions between the silicofluorides and other factors associated with lead uptake. Communities using silicofluorides also report higher rates of learning disabilities, ADHD, violent crime, and criminals who were using cocaine at the time of arrest.
Research conducted with Myron J. Coplan (Intellequity, Natick, MA) and Brian Hone under grants from the Office of Criminal Enforcement, Forensics and Training, Environmental Protection Agency, the Earhart Foundation, and the Rockefeller Center for the Social Sciences, Dartmouth College.
Poisoning the Well: Neurotoxic Metals, Water Treatment, and Human Behavior
Roger D. Masters
I.Heavy metals, Neurotransmitter deregulation, and Anti-social Behavior
A. Toxic heavy metals such as lead, manganese and cadmium, combined with prenatal or neonatal developmental insults, dietary deficits, and stress, damage the brain structures and down-regulate essential neurotransmitters. Previous research in this area has found:
1. Because lead and other toxic metals are retained in bone and astroglial cells in the brain, uptake during fetal development and early childhood has long-lasting effects on development and behavior.
2. Among the toxic effects of lead is a reduction of dopamine function (which disturbs the behavioral inhibition mechanisms in the basal ganglia) and glutamate (which plays an essential role in the long term learning associated with the hippocampus).
3. Manganese can downregulate serotonin function, reducing sociability and increasing aggressiveness or depression.
B. Prior research at the individual level showed that the uptake of heavy metals is associated with higher levels of learning disabilities, hyperactivity, substance abuse, violent crime, and other forms of anti-social behavior.
1. In seven different samples of prison inmates, violent offenders had significantly higher levels of lead, cadmium, or manganese in head hair than non-violent offenders or controls.
2. In two prospective studies, high lead levels at age 7 (one measuring lead in blood, the other bone lead) predicted juvenile delinquency and adult crime.
3. A substantial proportion of individuals diagnosed with ADD/ADHD are likely to have dangerously high levels of lead, manganese, or cadmium in bodily tissues.
4. Because alcohol, cocaine and other drugs temporarily restore neurotransmitter functions that are abnormal, substance abuse may often be crude self-medication in response to the effects of toxicity. For example, because lead downregulates dopamine and cocaine is a non-selective dopamine reuptake inhibitor, lead toxicity could increase the risk of cocaine abuse.
II. Heavy Metals, Blood Lead and Crime
A. Our own research shows that, for all U.S. counties, communities with industrial releases of lead or manganese had, controlling for socio-economic and demographic factors, higher violent crime rates in 1991. The comparable multiple regression analysis for 1985 replicates this finding.
B. Across the U.S., rates of violent crime and drug use have fallen continuously since 1993. This effect may be explained by long-term benefits of the ban on leaded gasoline in the 1970's. The delay reflects the years needed before the appearance of teenage cohorts that had not been exposed to leaded fumes during fetal development and early childhood.
1. Leaded gasoline was worse than lead toxicity in paint or water, since aerosol lead is absorbed 40-50% whereas only 5-15% of ingested lead is retained in the body.
2. Leaded gasoline sales from 1950 to 1980 are highly correlated with the overall violent crime rate 18 years or later (r = .902 or higher).
3. The effect confirmed by correlating leaded gasoline sales from 1950 to 1980 with homicides by teenagers aged 14 to 17, which drop more sharply after 1993 than those by older offenders.
4. The negative effects of leaded gasoline on impulse control are also suggested by the high correlation (r = .811) between leaded gas sales between 1949 and 1993 and the contemporary year's sales of hard liquor -- a pattern that is not found for the consumption of beer or wine.
III. Water Treatment Procedures, Lead toxicity and crime.
A. The agent used to fluoridate public water supplies was shifted from sodium fluoride (NaF) to fluosilicic acid (H2SiF6) or sodium silicofluoride (Na2SiF6) -- the silicofluorides (SiF) -- on the basis of questionable biochemical assumptions and without adequate testing.
1. Although virtually all studies of fluoridation have continued to use NaF, over 90% of Americans drinking fluoridated are exposed to supplies treated with SiF.
2. Although it is claimed that SiF is completely dissociated after injection in water supplies, this assumption is inconsistent with published research and is highly unlikely under the actual conditions of water treatment.
B. Because sodium fluoride and silicofluorides have very different biological effects, undissociated SiF residues may be dangerous.
1. As early as 1935, animal studies showed that excess fluoride derived from SiF is excreted through the kidneys, whereas fluoride residues from NaF are more likely to be excreted in feces (indicating more active fluorine transport across the gut-blood
barrier after exposure to SiF).
2. Recent research on dental preparations shows that SiF compounds may be as much as 19 times more biologically active than NaF.
3. Through one of several plausible mechanisms, SiF treated water can increase the transport of heavy metals across the gut-blood and blood-brain barriers, increasing rates of toxic uptake and behavioral dysfunction.
IV. Communities using SiF have higher levels of lead in children's blood and higher rates of anti-social behavior than locations with nonfluoridated or NaF treated water.
A. In Massachusetts, communities using SiF to fluoridate have higher rates of children with over 10µg/dL of blood lead and higher rates of crime.
Average levels of lead in children's blood were:
H2SiF6 = 2.78 µg/dL; Na2SiF6 = 2.66 µg/dL;
NaF = 2.07 µg/dL; non-fluoridated = 2.02 µg/dL.
1. Within Massachusetts, those communities where the EPA reported lead levels in water over 15ppb, this effect was more pronounced:
H2SiF6 = 3.27 µg/dL; Na2SiF6 = 4.38 µg/dL;
NaF = 1.90 µg/dL; non-fluoridated = 2.18 µg/dL.
2. These effects were confirmed in a matched sample of 30 SiF and 30 non-SiF suburban middle-class communities:
1.94% of children exposed to SiF treated water had blood lead over 10µg/dL, whereas only 0.76% of children not so exposed had blood lead over this level (risk ratio = 2.55).
3. Rates of crime were also higher in Massachusetts communities using SiF fluoridation.
4. Similar effects were confirmed in rural counties in six additional states (Georgia, Wisconsin, Texas, Illinois, Alabama, and North Carolina).
B. Among 30,000 criminals in 24 cities studied by NIJ, those living where SiF is in water were more likely to have been using cocaine at the time of their arrest
(H2SiF6 = 44%; Na2SiF6 = 43%; non-fluoridated = 32%).
1. There was no comparable difference for other drugs whose usage is not associated with chemicals influenced by lead toxicity.
2. Crime rates in the cities using SiF were significantly higher than in non-fluoridating cities
(H2SiF6 = 1486 per 100,000; Na2SiF6 = 1480 per 100,000; non-fluoridated = 1100. per 100,000), as were rates of death from alcoholism (H2SiF6 = 56.1 per 100,000; Na2SiF6 = 53.8 per 100,000; non-fluoridated = 44.1 per 100,000). ...
Geographic analysis of data from NHANES III shows that in counties where over 90% of the children receive SiF treated water, average blood lead is 5.1 µg/dL, compared to 3.7µg/dL where less than 10% of the children are exposed (risk ratio = 1.38). This effect is highly significant (p < .0001) both for children 3-5 and for those 5-17.
1. Minorities are especially at risk. In high SiF exposure counties, blood lead levels average
6.26 µg/dL among Black children,
4.86 µg/dL among Mexican-Americans,
and 3.05 µg/dL among Whites;
in low SiF exposure counties,
Blacks average 4.37µg/dL,
Mexican-Americans 3.86µg/dL, and
Whites 2.03µg/dL (risk ratios between 1.26 and 1.50).
For both 3-5 and 5-17 age-groups, the interaction effect between a child's race and SiF exposure as factors in higher blood lead is highly significant (p < .0001).
2. Although NHANES III data also shows some benefits of fluoridation on lower tooth decay, these effects are weaker and are not found among White children aged 5-17. Moreover, lower rates of caries are not found among children 15-17 (perhaps because fluoride can slow tooth eruption, which could lead to misleading data when comparisons match age for children of different races).
C. A preliminary survey of high school nurses and administrators in sixteen comparable middle sized New York cities shows higher rates of ADHD cases treated with medication and higher rates of learning disabilities in communities using SiF (risk ratio = 1.38).
V. Conclusion: the need to integrate neurotoxicology, environmental research and the study of human behavior.
A. The brain is the most sensitive chemical organ in the body. While discussions of toxins heretofore focused on cancer and disease, ADD/ADHD, alcoholism, substance abuse, and crime need to be studied in terms of the latest biology and neuroscience of early development and brain function.
B. The effects of toxic heavy metals are consistent with the perspective of Darwinian medicine: since lead and manganese are widely found in soils but uptake depends on dietary deficits in calcium and other key elements, for most of hominid evolution the effects discussed above would only have occurred in time of dietary shortfall, when increased male-male conflict was not necessarily mal-adaptive.
C. In contemporary society, these effects take on a different character. Environmental pollution and dangerous water treatment procedures are human activities whose results are both economically costly and morally unjust. Innocent children should not be poisoned by public water supplies.
Roger D. Masters, Ph.D. - Biography
Roger D. Masters is Nelson D. Rockefeller Professor Emeritus in the Dartmouth College Department of Government. He heads the Dartmouth Foundation for Neuroscience and Society. For several decades he has researched the causes of violence and other dysfunctional human behavior such as ADD, ADHD, drug abuse and the like. His viewpoint, which has been published widely, is that toxins in the environment have subtle effects on brain and neural functions which are ultimately manifested in behaviors which many social scientists and politicians prefer to attribute to social dynamics.
Dr. Masters presented a groundbreaking study related to lead and silicofluorides at the recent 17th International Neurotoxicology Conference ( "Children's Health and the Environment," Little Rock, Arkansas, October 17-20, 1999).
Below are a few relevent excerpts from his Curriculum Vitae: Education:
Harvard College, 1951-55 (., Summa cum Laude, 1955)
University of Chicago, 1957-58 (M.A., 1958)
Institut d'Etudes Politiques, Paris, 1958-59 (Auditor)
University of Chicago, 1959-61 (Ph. D., 1961)
Subject: Re: Murray: Kessler: lab tests of aspartame toxicity 1.15.01
Date: 21 Jan 2001 09:39:51 EST
From: Roger.D.Masters@Dartmouth.EDU (Roger D. Masters)
many thanks for your very helpful message.
A follow-up question.
I'm intrigued by the possibility of INTERACTIONS in brain chemistry when aspartarme interacts with other neurotoxins as they result in deficits or problems in BEHAVIOR. We work on geographic differences in rates of children's blood lead, ADHD, substance abuse, crime, etc. Behavioral psychologists and cognitive neuroscientists don't usually look at this sort of thing, and most toxicologists have not even thought of the brain as the most sensitive target organ. We have epidemics of NEW conditions (ADHD, autism, asthma, chronic fatigue syndrome, substance abuse, violent behavior etc.) Our data show that it is NOT entirely poverty or other social factors, since controlling for such things, toxins play a major role.
If you can get GEOGRAPHIC data for anything like this and someone to collaborate (we are flat out), I would love to see if we could correlate TOXINS as well as sales of products with aspartarme with some well defined outcome condition. ADHD is a very POOR outcome measure, because the standards of classification are so poor (rates are inversely correlated with school size, which merely means that teachers/nurses in small schools do a better job of diagnosis because they know families). How about autism or asthma? What I think will turn things around FAST is a behavioral horror that costs families endless misery as well as money and fear when living with children with debilitating conditions.
Comments by Rich Murray firstname.lastname@example.org
Just Jan 7, 2001, I was amazed to find email@example.com , Gluten Free Casein Free Kids, a support group with 1694 members, started Dec 16 1998, with a fully searchable archive of 54,187 posts, focused on treating autism, ADHD, and rage with pure diet. It took only a few minutes to search the archives and find reports by parents of kids who react severely to aspartame and MSG. Judy DeHart is editor for the main website http://www.gfcfdiet.com/ , which includes a thorough 234K review by Jeff Bradstreet, MD, FAAFD, The International Autism Research Center, 321-953-0278, firstname.lastname@example.org, which includes the harmful effects of aspartame, MSG, mercury (mainly from dental amalgams),
lead, and other toxins.
This is a prime example of an entirely new social process for medicine and research, in which large numbers of clients, scattered around the world, cooperate with qualified professionals to generate very fast discovery of effective treatment and preventive regimes, with rapid, personal dissemination, and constant, archived feedback on every detail, free of control by criminal, albeit perfectly legal, corporations and corrupt government agencies.
I soon located a long review on curing autism by eliminating mercury exposure, by Amy S. Holmes, MD
http://healing-arts.org/children/holmes.htm , as well as
"Autism: A Unique Type of Mercury Poisoning" 272K
Sallie Bernard email@example.com
Autism Research Center Research, Cranford, NJ 07016
There are almost 0.5 million cases of autism in the USA. If you search for "autism" at http://www.eGroups.com , you recover 338 relevant discussion groups, all free-- a discrete level of advertising supports eGroups, now part of Yahoo.
These kind of client-professional networks typically feature a high level of particiapation by female persons.
One of the best resources for ferreting out the existence of these networks is by using http://www.google.com , and searching, for instance, autism, mercury. The returns will include posts from the relevant eGroups archives. It is probable that these ever expanding archives will be maintained for all history as a permanently useful record of a revolution in democratic medical research, education, and practice. Already, many people are checking every problem, drug, and treatment by immediate searches on the Net. The Net has been widely available only since 1995.
I just started a policy of drinking and cooking only with deionized water, delivered to my door for about $ 6 for 5 gallons in glass jars, in Santa Fe, New Mexico, after reading in The New Mexican that city water had 9 ppm arsenic-- the legal limit in Europe is 5 ppm,
just lowered in the USA from 50 to 10 ppm.